NDP451-KB2858728-x86-x64-AllOS-ENU 4 is part of a product called known as Microsoft .NET Framework 4.5.1 and the developer is Microsoft Corporation .
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If NDP451-KB2858728-x86-x64-AllOS-ENU 4 is using too much CPU or too much memory in your system, it is possible that your file has been infected with a virus. Installing an antivirus is recommended.
Not all processes can be uninstalled without the help of a 3rd party tool, especially malware. To see if it can be uninstalled, first go to Start > Control Panel > Add/Remove programs and select Microsoft .NET Framework 4.5.1 from the list to remove the process NDP451-KB2858728-x86-x64-AllOS-ENU 4 from your computer.
If you have any problems with NDP451-KB2858728-x86-x64-AllOS-ENU 4, you may try using a registry cleaner or a speed-up software to check, analyze, and fix problems that are affecting the performance of your computer.
You may try contacting Microsoft Corporation, the developer of NDP451-KB2858728-x86-x64-AllOS-ENU 4 and ask for more information.